For Women With Very Low Body Weight, High Amounts of Exercise Can Result in:

Abstruse

There is evidence to support that low fitness and physical activity, backlog body weight, and excess abdominal fatness are associated with increased health risk. Moreover, prove exists to support that sufficient levels of physical activity can significantly improve trunk weight, fatness, and health risk. Concrete activity has been shown to have a minor upshot on trunk weight that is typically <iii% of initial body weight, but has an additive issue when combined with dietary restriction. Moreover, physical activity has been shown to be an important behavioral gene for enhancing long-term weight loss and minimizing weight regain; nevertheless, this may require relatively high doses of physical activeness that approach 300min/week. Physical activeness may meantime reduce abdominal adiposity, and which may serve as a pathway by which there is as well an improvement in health-related take a chance factors for various chronic diseases. There are important areas of research that require further investigation, with particular need to further examine the dose of physical activity that significantly affects these wellness outcomes. Moreover, there is a demand for improved interventions to promote the adoption and long-term maintenance of concrete action, which can lead to improved weight control, abdominal adiposity, and chronic disease risk factors. Future research is as well needed to understand the physiological/metabolic pathways and mechanisms that explicate the influence of concrete activity on long-term regulation of body weight.

Excess body weight has been associated with an increase in health-related diseases such as center disease, diabetes, certain forms of cancer, musculoskeletal disorders, and other related problems ((i)). The morbidity and mortality of obesity-related conditions accept resulted in an increase in the associated wellness-care cost of these conditions. For example, in the U.s., the estimated cost associated with obesity exceeds $117 billion annually ((ii)). Thus, it is important to consider intervention opportunities to lower the wellness risk associated with obesity, which in turn may reduce the wellness-care costs associated with these conditions. I of the lifestyle-intervention opportunities that has been shown to be effective is concrete activity due to its importance in body-weight regulation and its contained effect on related health outcomes.

There have been numerous studies that have reported on the importance of physical activity for weight control. These studies have focused on prevention of weight gain, successful weight loss, and the prevention of weight regain. The involvement in physical activeness as a lifestyle strategy to combat the increasing prevalence of overweight and obesity stems from the fact that it is the ane method that can exist consistently used to increase free energy expenditure. Every bit highlighted by Ravussin and Bogardus ((3)) physical activity is the almost variable component of total daily free energy expenditure. Therefore, it is important to sympathise the contribution of an increase in free energy expenditure resulting from concrete activity on weight loss, long-term weight-loss maintenance, and the prevention of weight gain. Optimal weight control through physical action may as well contribute to reductions in abdominal adiposity and reductions in metabolic take chances.

Does Physical Activity Affect Health Adventure Independent of Body Weight?

There is a growing body of scientific literature to support the effect of physical activeness on health-related outcomes independent of body weight. For case, data from the Aerobics Center Longitudinal Study has consistently shown an inverse relationship between fitness and mortality in adults regardless of level of weight condition (normal weight, overweight, obese) ((4),(5),(6),(7)). The pattern of an inverse association between health risk and physical activity, independent of weight status, is also supported by a number of other investigations ((8),(ix),(10)). Lee et al. ((eleven)) have as well reported an association between improved risk factor profiles and fitness at varying levels of abdominal adiposity measured past either computed tomography or magnetic resonance imaging.

Despite these findings, there is evidence to support the position that physical action does not completely convalesce the negative health outcomes associated with obesity ((8),(ix),(ten)). This determination is consistent with the findings of Wing et al. ((12)) in a report of over 5,000 individuals with blazon 2 diabetes, which demonstrated that selected chance factors were significantly influenced by weight status (e.m., systolic blood pressure) whereas others were significantly influenced past fitness (due east.g., HbA1c, ankle brachial index, Framingham Risk Score). Moreover, both physical activeness and a smaller waist circumference accept recently been shown to exist associated with classification of enhanced metabolic health (presence of 0 or 1 cardiometabolic abnormality) in obese individuals ((13)). These results may suggest that information technology is important to intervene on both concrete inactivity and excess body weight to have the greatest comeback in health outcomes.

A potential surface area for additional enquiry related to the independent effect of physical activity on health risks in obese individuals may lie in the study of individuals with Class II (BMI: 35.0–39.9 kg/m2) or III obesity (BMI ≥twoscore kg/mtwo). Church et al. ((5)) acknowledged that there are limited data on the relationship betwixt fitness and weight condition among individuals with Class II or III obesity when examining information from the Aerobic Eye Longitudinal Study due to few individuals with this weight status being classified as fit. This observation is confirmed by Wing et al. ((12)) in analysis of data from the Look AHEAD Written report in which only 10% of individuals with Form III obesity were in the highest 40% for fettle classification, with only one.8% of individuals in the highest tertile for waist circumference beingness in the highest fitness category. These findings may advise that it may be hard and uncommon for individuals in the highest categories of obesity and/or waist circumference to be able to accomplish sufficiently high levels of fitness to better health outcomes independent of concomitant reductions in body weight. Again, this may advise that for some individuals, it is important to arbitrate on both physical inactivity and excess torso weight to take the greatest improvement in wellness outcomes.

Effect of Physical Activity on Weight Loss

To finer reduce torso weight it is widely accepted that a negative free energy balance needs to be present; whereas, to maintain weight loss and prevent weight proceeds, free energy balance needs to be present. Thus, physical action can be an important intervention to achieve desired body-weight regulation. Still, the outcome of concrete activity alone on reductions in body weight may be somewhat modest. For example, in a study of overweight and obese adults at risk for the onset of type 2 diabetes, Wing et al. ((14)) compared interventions consisting of diet lone, physical activity lone, and the combination of diet plus physical activity. Results following the initial 6-month intervention period revealed weight losses of 9.ane, 2.1, and 10.four% in these intervention conditions, respectively, with weight loss in the physical activity solitary conditioning beingness significantly less than the weight loss in the diet alone and diet plus physical activeness weather condition. In a report of men, Wood et al. ((xv)) reported that weight loss in response to concrete action was iii.0 and 4.0 kg at 7 and 12 months, which was significantly less than the 7.6 and 7.ii kg weight loss observed in response to a dietary intervention. In response to a 12-week intervention, Hagan et al. ((16)) report significantly less weight loss for men and women (0.six%) in response to physical activity solitary compared to 8.4 and 5.5% in response to dietary brake alone, and compared to 11.4 and 7.5% in response to the combined effects of diet plus concrete action. These data appear to betoken that physical activity has a modest bear on on short-term weight loss in overweight and obese adults.

Donnelly et al. ((17)) examined supervised physical activeness of 45min/day on five days/week over a xvi-calendar month flow in overweight and Class I obese adults. The results of this study demonstrated that when dietary intake is unchanged, for men concrete activeness resulted in weight decrease of 5.two kg vs. a 0.5 decrease observed in non-physical-activity control men. In dissimilarity, physical activity for women blunted weight gain with weight increasing by 0.vi kg in exercising women vs. a two.9 kg increase in non-physical-activity control women. The concrete activity also resulted in significant reductions in abdominal adiposity as measured by computed tomography. For males, nonsignificant differences at 16-month that favored the concrete action vs. the control conditions were observed for visceral fat (difference of 9.nine cm2), subcutaneous fat (divergence of 23.two cm2), and total fat (difference of 33.two cm2). For females, differences favoring the physical activity vs. the control group at 16-months were observed for visceral fat (difference of 8.6 cm2; P = 0.88), subcutaneous fat (difference of 53.iii cmii; P = 0.02), and total fat (difference of 61.9 cm2; P = 0.04) with the pattern of modify in abdominal adiposity mirroring the observed changes in body weight between genders. These gender differences may exist a result of the supervised physical activeness resulting in different energy expenditures, with the average energy expenditure for each physical activity session 667 kcal (6.7 kcal/kg of fat-costless mass) in men vs. 438 kcal (5.four kcal/kg fat-gratis mass) in women ((xviii)). Thus, the observed gender differences may be a event of differences in energy expenditure resulting from physical activeness. Thus, it will exist of import for future studies to examine whether clamping energy expenditure will result in similar changes in body weight in men and women.

The scientific evidence presented in the Concrete Action Guidelines Committee Report in the Us (http:www.health.govPAguidelines) confirms that concrete alone typically results in weight change of <3% of initial trunk weight, with accented weight loss ranging from ∼0.5 to 3.0 kg. This is consequent with the magnitude of 2.4 kg reported by the National Heart, Lung and Blood Establish's Adept Panel ((1)), and the 1–2 kg reduction in body weight reported in a review conducted past Wing ((19)).

This small magnitude of weight loss resulting from physical activity alone is consistent with the definition of "weight stability" as defined by Stevens et al. ((xx)), suggesting that a greater dose of physical activity or physical activeness combined with reductions in energy intake may be required to elicit greater reductions in body weight. Notwithstanding, it is important to note that even pocket-sized reductions in torso weight may be beneficial for reducing cardiometabolic risk. For case, Wing et al. ((14)) reported that a 2.3 kg reduction in body weight over a menstruation of 24 months from physical activeness or the combination of diet plus physical action decreased the relative risk of developing diabetes by ∼30% in individuals initially identified with normal or dumb glucose tolerance.

Effect of Concrete Activity on Long-Term Weight Loss and Weight-Loss Maintenance

Although physical activity may have pocket-sized effects on initial weight loss, physical activity may exist a critically important strategy for the maintenance of weight loss. Jakicic et al. ((21)) have recently reported that relatively high doses of concrete activity may be important for the long-term maintenance of weight loss. In a secondary assay of data from a report of adult women, it was reported that individuals who achieved a weight loss of 10% of initial body weight that was maintained at 24 months were engaging in ∼275min/week of physical activity to a higher place baseline levels. Achievement of a ten% weight loss is consequent with the weight-loss target recommended by the National Heart, Lung and Blood Establish for overweight and obese adults ((1)). The importance of improved long-term weight loss in this report appears to also bear on sustained reduction in abdominal adiposity as measured past waist circumference, sagittal diameter, waist-to-hip ratio (Figure 1).

Details are in the caption following the image

Changes in (a) waist circumference, sagittal diameter, and hip circumference and (b) waist-to-hip ratio by 24-month weight loss (data adapted from Jakicic et al. ((21))).

These results confirm the importance of relatively high doses of physical activity to maintain weight loss as reported past others ((22),(23),(24),(25),(26)), and may confirm recommendations for weight-loss maintenance that have been reported ((27),(28),(29),(30)). This is of importance considering the maintenance of initial weight loss has been challenging. For case, it has been reported that following weight loss, ∼33–fifty% of initial weight loss is regained in the ensuing 12–eighteen months ((31)). Notwithstanding, physical activity appears to play a fundamental role in the long-term maintenance of weight loss, which may ultimately upshot in sustained improvements in metabolic hazard.

The National Weight Control Registry (NWCR) is a registry of individuals who have self-reported to accept lost at least 30 pounds and have maintained this weight loss for at least 1 yr (ref. (25)). This provides interesting data related to the behaviors of individuals who have successfully lost and maintained pregnant weight loss. Of interest is the blueprint of physical activity in this cohort. Klem et al. ((25)) report that individuals in the NWCR cocky-report participating in ∼2,800 kcal/week of leisure-time physical activity to maintain their body weight. McGuire et al. ((32)) further highlight the importance of concrete action for weight-loss maintenance by reporting that individuals in the National Weight Control Registry who regained weight after one year in this registry reported greater decreases in energy expenditure when compare to those individuals who continued to maintain their significant weight loss.

Evidence of the importance of physical activity for maintenance of weight loss is not limited to the National Weight Control Registry. For example, Kayman et al. ((33)) reported that 76% of individuals who had maintained significant weight loss reported using concrete activity as a weight-loss strategy vs. 36% of individuals who relapsed from initial weight loss. When comparing individuals who had maintained a weight loss of xv pounds vs. those who had relapsed, Gormally and Rardin ((34)) found that 54% of maintainers reported regular physical activity vs. 36% of those who had relapsed. Moreover, Leser et al. ((35)) reported that cocky-reported physical action was inversely correlated (r = −0.53) with weight regain at a 3-year follow-upward to a very-depression-calorie diet intervention for weight loss. Concrete activeness was also shown to be predictive of maintenance of weight loss following an intervention involving pharmacotherapy ((36)). Despite these findings, it is important to note that concrete activity is just 1 component of successful weight-loss maintenance, with Jakicic et al. ((37)) reporting that long-term weight-loss success is achieved through a constellation of behaviors, i of which is physical activeness.

Effect of Physical Action on Prevention of Weight Gain

As reported by Jakicic et al. ((21)), ∼27% of individuals engaged in a behavioral weight-loss intervention achieved a ten% weight loss at 24 months, with 49% of individuals achieving at least 5% weight loss. This confirms the difficulty of achieving long-term weight loss as reported by others ((31)). Thus, it may exist of import to focus intervention efforts on prevention of weight gain and obesity, and physical activity may exist an important component of intervention efforts to prevent weight gain.

Results from cross-exclusive and prospective observational studies appear to support the need for adequate levels of physical activity to prevention weight proceeds. Lee et al. ((8)) demonstrated from cross-exclusive information that individuals who report levels of physical activity that are consistent with the consensus public health guidelines have a lower torso weight than those not reporting this level of concrete activity ((eight)). A potential limitation of this study is the self-reported cess of concrete activity. Brawl et al. ((38)) followed a accomplice of 8,726 young women (age = xviii–23 years) for a period of 4 years to examine predictors of weight maintenance. Results from this study demonstrated that 41% of these young women gained weight over this period of fourth dimension, which was divers equally gaining ≥5% of their initial body weight. Individuals who reported spending ≥33h/week sitting were 17–twenty% more likely to gain weight compare to those reporting sitting <33h/week. These results are consistent with other studies that take demonstrated sedentary behavior such as goggle box viewing to exist associated with increasing levels of torso weight and obesity ((39)). A potential mechanism for this relationship is that a higher level of television viewing is associated with a lower resting metabolic rate in children ((twoscore)). Still, an alternative hypothesis would be that sedentary activities reduce the opportunities for physical activity, which results in an overall reduction in energy expenditure. Therefore, additional studies are required to conclusively determine how sedentary behaviors such as sitting and television viewing contribute to weight proceeds and obesity.

In a study that used an objective measurement of cardiorespiratory fitness, it was reported that weight gain was attenuated over a 4-twelvemonth period as cardiorespiratory fitness increased over this same ascertainment period ((41)). Cardiorespiratory fitness has been shown to ameliorate with increased levels of physical activity. Therefore, these findings may reflect an increase in physical action, with this contributing to the prevention of weight proceeds. In a study to examine predictors of weight gain in the Good for you Worker Project, French et al. ((42)) reported that over a 2-yr period the average weight gain was 0.six kg for women and 0.4 kg for men. Results of this study demonstrated that an increment of 1 walking session per week was predictive of a decrease in body weight over the ii-year period of 0.eight kg and 0.4 kg in women and men, respectively. Yet, these levels of concrete activity combined with dietary behaviors and weight-loss history accounted for ∼9–10% of the weight loss observed.

In that location is likewise evidence from intervention studies supporting the importance of physical activity in the prevention of weight gain. Sherwood et al. ((43)) report that concrete action was predictive of weight change in the Pound of Prevention Study. Results of multivariate cross-sectional analysis revealed that moderate-intensity physical action was predictive of less weight proceeds in this study; whereas multivariate prospective assay revealed that high-intensity physical action was predictive of weight change over the 3-year menstruum. When examining data from intervention studies, the effect of concrete activity on weight gain may result from the not-concrete-activeness control group gaining a minor amount of weight with those individuals participating in concrete activity losing a modest amount of weight. For example, Slentz et al. ((44)) reported that physical activity resulted in a modest decrease in body weight and measures of torso fatness, whereas control subjects not participating in physical activity had a modest increase in torso weight in the STRIDDE Report.

Summary

In summary, based on the scientific evidence, it appears that physical activity tin can exist an important component of intervention efforts for body-weight regulation. These findings are important equally it appears that there is a concurrent reduction in abdominal adiposity with weight loss resulting from concrete activity. All the same, the weight loss achieved with concrete activity lone appears to exist small and is typically <3% of initial body weight. However, the improver of physical action to a dietary intervention can consequence in improved weight loss compared to what is achieved through dietary modification lonely. Moreover, it appears that physical action is a key lifestyle behavior in longer term weight loss and the maintenance of weight loss. Still, as summarized in the Physical Activity Guidelines Advisory Commission Report, boosted research is needed to fully empathize the contribution of physical action to body-weight regulation ((45)). In general, these areas of research include the following:

i. Appropriately designed and powered studies are needed to understand the upshot of unlike modes, intensities, duration, and frequencies of concrete activity on weight loss, weight stability, and weight regain.

2. In that location may be a demand for farther research to understand how demographic characteristics such as historic period, gender, race/ethnicity influence the effect of physical activity on weight loss, weight stability, and weight regain.

3. At that place is a need for further enquiry to be conducted that focus specifically on behavioral strategies that improve the adoption and long-term maintenance of physical activity in overweight and obese adults.

iv. There is a need to examine whether the dose of physical activity that promotes improved long-term outcomes of weight control is different from the dose of physical activeness that results in improvements in chronic disease hazard factors and the onset of chronic illness beyond the entire range of torso weight including those with severe obesity (e.yard., Class 2 and Class 3 obesity).

Disclosure

J.Yard.J. has received consulting fees and grant support from BodyMedia, Proctor & Gamble, Free & Clear, UPMC Health Program.

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Source: https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2009.386

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